Keďže Leukeran môže spôsobiť ireverzibilný útlm kostnej drene, u pacientov sa musí počas liečby pozorne sledovať krvný obraz. Leukeran je účinný cytotoxický liek, ktorý sa môže užívať iba pod dohľadom lekára so skúsenosťami s podávaním cytostatík. Pacienti so zriedkavými dedičnými problémami galaktózovej intolerancie, lapónskeho deficitu laktázy alebo glukózo-galaktózovej malabsorpcie nesmú užívať tento liek.
Leukeran sa podáva perorálne a má sa užívať denne na lačno (aspoň jednu hodinu pred jedlom alebo tri hodiny po jedle). Leukeran v terapeutickej dávke spôsobuje útlm lymfocytov; slabší účinok má na neutrofily, trombocyty a na hladinu hemoglobínu. Keďže chlorambucil sa metabolizuje predovšetkým v pečeni, u pacientov so závažnou poruchou funkcie pečene sa má zvážiť zníženie dávky. Preukázalo sa, že chlorambucil spôsobuje u človeka chromatidové alebo chromozomálne poškodenie.
Ak je prítomná lymfocytárna infiltrácia kostnej drene alebo ak je kostná dreň hypoplastická, denná dávka nemá prekročiť 0,1 mg/kg telesnej hmotnosti. Leukeran sa nemá podávať pacientom, ktorí v nedávnej minulosti podstúpili rádioterapiu alebo dostávali iné cytotoxické látky. Výskyt nežiaducich účinkov sa môže líšiť v závislosti od užitej dávky a tiež od toho, či sa Leukeran podal v kombinácii s inými liekmi.
Chlorambucil môže spôsobiť supresiu funkcie ovárií; po liečbe chlorambucilom bola popísaná amenorea.
Since chlorambucil can increase your pet's chance of getting an infection, try to keep your pet away from stray animals or animals that may have an infection. Drug information contained herein may be time sensitive. Pets who have demonstrated hypersensitivity to this medication should not be given the drug. Try to give this medication at about the same time(s) each day. Try not to miss giving any doses. Amaryl's devotion to his work would be his undoing, giving him an early death from overwork.
DO NOT stop giving this medication unless directed by your veterinarian. It is recommended that you wash your hands after administering this medication. Avoid exceeding the recommended dosage unless instructed by a healthcare professional. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, Acivir Pills : Traitement Antiviral Efficace Contre l’Herpès the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient.
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In 2010, one year after Yasmin's death, Kevin Bathman, a Malaysian visual artist who resides in Sydney, opened a digital art exhibition and film screening, named In Her Own Words: A Celebration of Humanity and Universal Love, as a tribute to Yasmin's life and legacy.
