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Shortly afterward, on May 8, a team, led by Columbia University doctors Daniel Freedberg and Julian Abrams, Valutazione del Prodotto posted a study on the preprint server medRxiv that compared the outcomes of people with COVID-19 who were prescribed famotidine within 24 hours of being admitted to the hospital to those who didn’t get the heartburn drug.
According to the study, they were far less likely to die or require a ventilator-a twofold decrease in risk-than those not receiving the drug. So the study was designed to compare patients receiving hydroxychloroquine and famotidine with patients receiving hydroxychloroquine and a placebo. Learn how they compare. Those authors recommend a clinical trial with famotidine be carried out with patients with milder disease in addition to the trial going on at Northwell hospitals. For clarity on famotidine’s effectiveness, the team recommends awaiting the outcome of the trial going on at Northwell hospitals.
But the Northwell trial has slowed for two reasons, says Joseph Conigliaro, the physician who is leading it.
"We need to wait for the results of our trial," he says. Carl J. Lavie, medical director of cardiac rehabilitation and Kundenstimmen prevention at the John Ochsner Heart and Vascular Institute, recently cowrote a letter to the editor of Mayo Clinic Proceedings encouraging doctors to wait for the clinical trial results.
It was filmed in Italy by director Raoul Walsh. Matthew D. Hall, acting director of biology and group leader, Early Translation Branch, at the National Center for Advancing Translational Sciences (NCATS), part of the US National Institutes of Health, points out that his group did studies in cells that show famotidine doesn’t have any ability to fight SARS-CoV-2. Read about the signs and symptoms of drug-induced liver disease like hepatitis (inflammation of the liver cells), liver disease treatment, and types.
If it worked, it would be a fast and cheap way to ease the symptoms of COVID-19. He tells C&EN that it’s premature to recommend famotidine just for COVID-19, but he adds, "I also think that it is benign, so it would seem very reasonable to use for upper GI symptoms now" before giving other heartburn drugs like omeprazole.
